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Pragmatic trials are trials designed to inform the practice of clinical trials in real life. They are often described as focusing on practical aspects of study design, including recruitment and consent, adherence and the use routinely available equipment.
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While Pragmatic Play is known for its slot machines, they also offer table games such as Bitcoin baccarat and Roulette. They have more than dozen licensed games and their software is well-known for its reliability and security. Their games are available in multiple languages and include a variety of betting options, including live dealer tables.
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Pragmatic, a software company offers a range of casino games for online gambling platforms. Its iGaming solutions are utilized by the leading operators and land-based casinos. The company provides front-end site design tools, analysis tools and promotions, marketing security payment systems, customer support and bug reporting. Additionally, the company offers its players a safe and secure environment with high-quality graphics and gaming.
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Pragmatic Play, one of the most popular iGaming firms offers a wide selection of slot games. Certain of these games feature high RTPs which allow players to maximize their potential to win. Many of the company's games also support mobile devices which makes them suitable for playing on tablets and smartphones. Some of these games include an extra game that allows players to win free spins.
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A pragmatic study that involves various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for pragmatic trials to be able to prove their validity and helps to reduce the chance of bias in the results. However, too much heterogeneity could cause issues with the trial design.
Pragmatic Play, one of the major players in the live casino market, offers various classic table games, including Blackjack and Roulette. Pragmatic Play's live studios in Romania and Malta provide a genuine gaming experience for its customers, as well as a full suite of virtual betting options. The company also has created numerous interactive game shows that make gambling online enjoyable. Some of these shows have live hosts, whereas others are hosted by famous personalities from the industry.
Mobile compatibility
Pragmatic Play, a relatively young player in the industry of online casinos, has gained a reputation for its mobile-friendly slot machines. Their games are optimized for mobile devices and are powered by HTML5 technology. They're also endorsed by trusted gaming authorities to ensure fairness and transparency. This is a great signal for players since it indicates that the games have been thoroughly tested and verified in order to ensure the randomness and fairness of each round.
In addition to their mobile-friendly slots, Pragmatic Play also offers live dealer casinos. Pragmatic Play is licensed and regulated by several governing bodies which include the Malta Gaming Authority and UK Gambling Commission. The games offered by the company are secured by top-of-the-line encryption and its security team is available to assist players in any situation.
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Legality
Pragmatic Play is renowned for its top-quality games and for offering an exceptional user experience. Its software can be used on mobile devices and in a variety of languages. It has been recognized as one of the leading casino gaming platforms despite its relatively young age. Wolves is one of its latest releases which is a five-reel slot machine that has a high RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.
Pragmatic trials seek to replicate real-world situations and have the highest external validity. They are usually commissioned by practitioners and policy makers to inform their decision making. They can also be a great method of determining the causal relationship between an intervention and its outcomes. However, they should not be used to substitute for explanatory studies.
The pragmatism concept is controversial and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which confirm the validity of a physiological or clinical hypothesis, and pragmatic trials that aid in policy and practice decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the elements of a practical study that includes the recruitment, design, and delivery of the intervention and its follow-up.
There is a positive increase in the number of pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs) resulted in 34 articles, shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to note that the majority of these trials were conducted in primary care settings.